Journal: Biomechanics and Modeling in Mechanobiology

Article Title: Computational models for predicting bone fracture healing: a review of modeling approaches, predictions, and emerging strategies

doi: 10.1007/s10237-026-02061-x

Figure Lengend Snippet: Rows a and b show the increase in tissue stiffness (E) over time, especially around the cortical bone and under the plate, with hard callus forming by day 21 (10–40 MPa). Row c shows MSC migration from high-density areas toward the fracture site, with notable accumulation under the plate by day 7 and saturation between days 7 and 14. Row d shows vascularization progression, with blood vessel growth in the callus by day 7 and stabilization of vessel density and oxygen levels by day 21, supporting tissue regeneration. Adapted from Razavi et al.

Article Snippet: FEM , Composite bone plates + blood vessel growth , 3D FE model of fractured human tibia with composite plate; ABAQUS v6.9.1; C3D8T elements; mechanoregulation and diffusion equations via Fortran user subroutines; blood vessel growth modulates callus stiffness; simulation over 112 days , Flexible Twintex \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\text {[0]}_{18}$$\end{document} [0] 18 plates promoted more mature bone (4000–5500 MPa) than stainless steel; vascular growth enhanced healing and reduced sensitivity to implant stiffness , Comparison with in vivo sheep data (gap size and IFM trends); tissue phenotype distributions vs histological data , Simplified geometry; constant load conditions; uniform vascular density; no patient variability , Son et al. ( ) .

Techniques: Migration